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EMBO Member

Ian D. Hickson

University of Copenhagen | Denmark

EMBO 2011

Chromosome maintenance through DNA repair

Our laboratory studies the mechanisms by which eukaryotic cells maintain genomic integrity. We use both model organisms and human cells to study how a breakdown in the maintenance of genome stability impacts on cancer and ageing. In recent years, we have focused on how RecQ helicases (e.g. BLM) suppress chromosome instability in S-phase through their actions in homologous recombination repair, and how defective replication impacts on mitosis.

Keywords: DNA repair / chromosome instability / chromosome segregation / homologous recombination / DNA helicases

Subject area(s): Cell Cycle | Genome Stability & Dynamics | Molecular Medicine