Cytochrome c signaling and phase separation
My research uncovers fundamental mechanisms governing mitochondrial-nuclear communication, electron-transfer pathways, and biomolecular condensate dynamics. Using structural, biophysical and cellular approaches, we reveal unexpected functions of cytochrome c in nuclear signaling and DNA damage responses, and establish how post-translational modifications shape phase separation and protein-RNA interactions in health and disease.
Keywords
Cytochrome c / DNA damage response / histone chaperone / intrinsically disordered domain / liquid-liquid phase separation / nucleolus / post-translational mofification