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EMBO Member

Irma Thesleff

Helsinki | Finland

EMBO 2000 | WpfC 01–04 | FelC 06–09

Development and regeneration of ectodermal organs

We explore the mechanisms that regulate the formation of ectodermal organs, including teeth, hairs and glands; specifically how signalling networks mediating intercellular communication regulate the patterns, numbers, sizes, and shapes of organs. We address the initiation and morphogenesis of organs, and the maintenance and differentiation of epithelial stem and progenitor cells in teeth. We use mouse models and ex-vivo tissue culture techniques.

Keywords: Morphogenesis / development of teeth, hair & glands / bone development / signalling networks / tooth renewal

Subject area(s): Development | Signal Transduction