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EMBO Member

Irun R. Cohen

Weizmann Institute of Science, Rehovot | Israel

EMBO 1994

Immune system regulation

I have discovered T-cell vaccination, now in phase II trials to treat MS, and HSP60 peptide therapy (DiaPep277) to arrest beta-cell destruction in Type 1 Diabetes, which has achieved primary & secondary endpoints in a phase III clinical trial. I am developing an antigen microarray chip for bioinformatic analysis of immune system profiles. I formulated the concept of the immunological homunculus, the immune system's image of key body molecules.

Keywords: Autoimmunity / T cell biology & therapy / cancer immunology / antigen microarray / antibody profiling / modeling / vaccines

Subject area(s): Genomic & Computational Biology | Immunology | Systems Biology