Ruder Boskovic Institute, Zagreb | Croatia
We investigate the biophysical principles underlying the mitotic spindle assembly and function. In our interdisciplinary approach, we combine cell and molecular biology, molecular genetics, biophysical tools including laser microsurgery, computer science, and theoretical physics. We are especially interested in the role of bridging fibers in spindle formation and force generation, as well as in the recently discovered chirality of the spindle.
Keywords: Mitosis / spindle / microtubules / motor proteins / kinetochore / mechanobiology / cell division / microscopy