University of Oxford | United Kingdom
Our lab is utilising biochemical and cell-based assays to study DNA damage response pathways, which should lead to better understanding of the mechanisms underlying disease. We are particularly interested in pathways and protein functions regulated by ADP-ribosylation. ADP-ribosylation is a posttranslational protein modification employed in regulation of DNA repair, chromatin structure, mitosis, transcription and many other processes.
Keywords: DNA repair / genome stability / PARP / ADP-ribosylation signalling / infection
Subject area(s): Microbiology, Virology & Pathogens | Proteins & Biochemistry | Signal Transduction | Chromatin & Transcription | Genome Stability & Dynamics