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EMBO Member

Ivan Ahel

University of Oxford | United Kingdom

EMBO 2022

ADP-ribosylation in regulation of genome stability

Our lab is utilising biochemical and cell-based assays to study DNA damage response pathways, which should lead to better understanding of the mechanisms underlying disease. We are particularly interested in pathways and protein functions regulated by ADP-ribosylation. ADP-ribosylation is a posttranslational protein modification employed in regulation of DNA repair, chromatin structure, mitosis, transcription and many other processes.

Keywords: DNA repair / genome stability / PARP / ADP-ribosylation signalling / infection

Subject area(s): Chromatin & Transcription | Genome Stability & Dynamics | Microbiology, Virology & Pathogens | Proteins & Biochemistry | Signal Transduction