EMBO Member
Ivan Dikic
EMBO 2004 | EEsC 08–12 | PubAB 09– | PubAB 17– | Council Member 23–25 | Council Member 26–28 | Council Vice-Chair 26–
Goethe University, Frankfurt, Germany
Ubiquitination and autophagy in health and disease
Major scientific interests of my lab are focused on understanding how ubiquitin serves as a cellular signal recognized and decoded by specific receptors to control multiple cellular functions, e.g we have shown how linear ubiquitin chains regulate NF-kappaB activation and innate immunity. In parallel we pioneered the concept of autophagy receptors in selective autophagy pathways regulating mitophagy, Salmonella infection and neurodegeneration.
Keywords
Cancer / endocytosis / ubiquitination / DNA repair / autophagy