Klinikum der Universität, Frankfurt | Germany
EMBO 2004 | EEsC 08–12 | PubC 09–09 | PubAB 09–
Major scientific interests of my lab are focused on understanding how ubiquitin serves as a cellular signal recognized and decoded by specific receptors to control multiple cellular functions, e.g we have shown how linear ubiquitin chains regulate NF-kappaB activation and innate immunity. In parallel we pioneered the concept of autophagy receptors in selective autophagy pathways regulating mitophagy, Salmonella infection and neurodegeneration.
Keywords: Cancer / endocytosis / ubiquitination / DNA repair / autophagy