
EMBO Member
Ivan Matić
EMBO 2024
Former EMBO Young Investigator (2019)
Cell Signaling and Proteomics of Aging
We use proteomics and chemical biology-based approaches to elucidate at the molecular level the role of ADP-ribosylation in biological processes. We are particularly interested in understanding how ADP-ribosylation by PARP1, an important target for cancer therapy, regulates the DNA damage response.
Keywords
ADP-ribosylation signaling / PARP1 / DNA repair / histone modifications / chemical biology / proteomics / modular antibody technology / serine ADP-ribosylation