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EMBO Member

Ivan Matić

Max Planck Institute for Biology of Ageing, Cologne | Germany

EMBO 2024

Proteomics and ADP-ribosylation signalling

We use proteomics and chemical biology-based approaches to elucidate at the molecular level the role of ADP-ribosylation in biological processes. We are particularly interested in understanding how ADP-ribosylation by PARP1, an important target for cancer therapy, regulates the DNA damage response.

Keywords: ADP-ribosylation signaling / PARP1 / DNA repair / histone modifications / chemical biology / proteomics / modular antibody technology / serine ADP-ribosylation

Subject area(s): Genome Stability & Dynamics | Proteins & Biochemistry | Signal Transduction