EMBO Member
Max Planck Institute for Biology of Ageing, Cologne | Germany
EMBO 2024
We use proteomics and chemical biology-based approaches to elucidate at the molecular level the role of ADP-ribosylation in biological processes. We are particularly interested in understanding how ADP-ribosylation by PARP1, an important target for cancer therapy, regulates the DNA damage response.
Keywords: ADP-ribosylation signaling / PARP1 / DNA repair / histone modifications / chemical biology / proteomics / modular antibody technology / serine ADP-ribosylation
Subject area(s): Genome Stability & Dynamics | Proteins & Biochemistry | Signal Transduction