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EMBO Young Investigator

J. Ross Chapman

University of Oxford MRC, Oxford | United Kingdom

YIP 2019–2023

DNA repair in cancer and genome diversification

My lab aims to define the molecular mechanisms that establish an appropriate equilibrium between accurate and mutagenic DNA repair pathways, and to understand why imbalances in this regulation result in cancer and human disease. We also conduct projects that aim to discover additional processes driving chromosomal instability in cancer, in the hope of identifying cellular defects that can be exploited to selectively kill cancer cells.

Keywords: DNA repair / adaptive immunity / cancer / DNA double-strand breaks

Subject area(s): Chromatin & Transcription | Genome Stability & Dynamics | Immunology | Molecular Medicine