Proteome and organelle quality control
We are interested in organelle and protein quality control, and the roles played by autophagy and the ubiquitin system in these processes, with a special focus on neurodegenerative disease. We use a variety of approaches, including quantitative proteomics, biochemistry, and cell based screens to uncover underlying molecules and mechanisms. We are also interested in the global architecture of human protein interaction networks.
Keywords
Ubiquitin / cullin-RING E3 ligases / autophagy / cell cycle / parkin