Université Paris-Saclay, Gif-sur-Yvette | France
My lab studies regulatory proteins that are essential to cell logistics, mainly small GTPases and their regulators. We use integrative structural biology approaches to investigate the mechanisms by which these proteins process information and assemble signaling platform at the surface of cellular membranes. We apply this knowledge to the discovery of inhibitors and the understanding of the molecular basis of diseases.
Keywords: Regulation of small GTPases / protein-membrane interactions / post-translational modifications / protein interaction inhibitors / structural biology & biophysics
Subject area(s): Structural Biology & Biophysics | Signal Transduction | Proteins & Biochemistry | Membranes & Transport