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EMBO Member

James C. Smith

Francis Crick Institute, London | United Kingdom

EMBO 1992

Molecular basis of mesoderm formation

The different cell types of the body are formed in the right place and at the right time in response to morphogens that act in a concentration-dependent manner to induce the formation of different cell types at different positions within the embryo. We study one of the earliest interactions of this kind is mesoderm induction, which results in the formation of organs and cell types such as heart, muscle, kidney and bone.

Keywords: Early vertebrate development / inductive interactions / growth factors / transcription factors / Xenopus / zebrafish

Subject area(s): Cellular Metabolism | Chromatin & Transcription | Development | Genomic & Computational Biology | Signal Transduction