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EMBO Member

James Sharpe

EMBL, Barcelona | Spain

EMBO 2019

Multicellular systems biology

Our group brings together an interdisciplinary team of biologists, physicists and computer scientists to build multi-scale computer simulations of a paradigm of organogenesis – mammalian limb development. To create and test these simulations, we combine quantitative 3D imaging, morphometrics, in vitro culture, and a variety of perturbation approaches, such as genetics, signalling inhibition, and physical manipulation of limb buds.

Keywords: Dynamic computer simulations / gene regulatory circuits / limb development / optical projection tomography / Turing patterns

Subject area(s): Development | Genomic & Computational Biology | Structural Biology & Biophysics | Systems Biology