Search    Show all

1 People found

filters applied:


1 / 1

EMBO Member

Jan H.J. Hoeijmakers

Erasmus University, Rotterdam | Netherlands

EMBO 1995 | FelC 02–03

DNA damage and repair, nutrition, cancer and aging

We cloned many human repair genes, elucidated mechanisms, generated mouse mutants and discovered that DNA damage causes transcription stress and aging, but also triggers an anti-aging response, alike calorie restriction (CR). CR strongly delayed accelerated aging in mouse mutants and patients. The clinical implications extend to counteracting neurodegeneration, side effects of chemo/radiotherapy, and surgery-related ischemia reperfusion injury.

Keywords: (Mammalian) DNA repair / human DNA repair syndromes / genetic (in)stability / cell cycle arrest / cancer & ageing

Subject area(s): Cell Cycle | Genome Stability & Dynamics | Molecular Medicine