Erasmus University, Rotterdam | Netherlands
EMBO 1995 | FelC 02–03
We cloned many human repair genes, elucidated mechanisms, generated mouse mutants and discovered that DNA damage causes transcription stress and aging, but also triggers an anti-aging response, alike calorie restriction (CR). CR strongly delayed accelerated aging in mouse mutants and patients. The clinical implications extend to counteracting neurodegeneration, side effects of chemo/radiotherapy, and surgery-related ischemia reperfusion injury.
Keywords: (Mammalian) DNA repair / human DNA repair syndromes / genetic (in)stability / cell cycle arrest / cancer & ageing