DNA damage and repair, nutrition, cancer and aging
We cloned many human repair genes, elucidated mechanisms, generated mouse mutants and discovered that DNA damage causes transcription stress and aging, but also triggers an anti-aging response, alike calorie restriction (CR). CR strongly delayed accelerated aging in mouse mutants and patients. The clinical implications extend to counteracting neurodegeneration, side effects of chemo/radiotherapy, and surgery-related ischemia reperfusion injury.
Keywords
(Mammalian) DNA repair / human DNA repair syndromes / genetic (in)stability / cell cycle arrest / cancer & ageing