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EMBO Member

Jan Steyaert

Université Libre de Bruxelles, Brussels | Belgium

EMBO 2020

Nanobodies as tools in structural biology

Our lab pioneered the use of nanobodies as tools in structural biology. The elucidation of the first GPCR structures in the agonist-bound active state demonstrate the power of nanobodies to stabilize protein conformational states and their complexes, including transmembrane signalling complexes. Our recent work focusses on nanobody-enabled drug discovery and on engineered nanobodies for applications in single particle cryo-EM.

Keywords: Nanobodies / GPCRs / x-ray crystallography / cryo-EM / membrane proteins

Subject area(s): Proteins & Biochemistry | Signal Transduction | Structural Biology & Biophysics