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EMBO Member

Jannie Borst

University Medical Centre, Leiden | Netherlands

EMBO 2012

Lymphocyte activation and survival

Our interest is to determine how lymphocytes and cancer cells decide between living and dying, with a focus on TNF receptor family members and their associated signaling pathways. Our work is aimed at improving immunotherapy of cancer and to contribute to the design of novel anti-cancer therapies by exploiting cell death signaling pathways.

Keywords: Cancer / lymphocytes / TNF receptor family / cell death signaling / costimulation

Subject area(s): Differentiation & Death | Immunology | Signal Transduction