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EMBO Member

Jean-Christophe Marine

KU Leuven | Belgium

EMBO 2020

Non-genetic mechanisms of cancer evolution

My laboratory focuses on the mechanisms by which cancer-specific non-mutational (i.e. epigenetic and (post-)transcriptional) events modulate tumor initiation, progression and therapy outcome. We harness the power of mouse genetics and patient-derived xenografts (PDX) as preclinical models, in order to study cancer gene function in the in-vivo relevant context and test novel (combination) therapeutic modalities.

Keywords: Cancer biology / therapy resistance / stem cells / intra-tumor heterogeneity / melanoma

Subject area(s): Differentiation & Death | Molecular Medicine | RNA