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EMBO Young Investigator

Jeffrey Chao

Friedrich Miescher Institute, Basel | Switzerland

YIP 2018

Post-transcriptional regulation in the cytoplasm

The aim of our research is to understand gene expression from the perspective of individual mRNAs. To this end, we use single-molecule fluorescent microscopy to image the lives of mRNAs in single cells and engineer novel RNA biosensors that enable specific events (e.g., translation or degradation) to be directly observed. We also use structural biology to understand the mechanisms used by RBPs to regulate the distinct stages of an mRNA's life.

Keywords: Translation / mRNA degradation / mRNA localization / RNA-protein complexes / single-molecule microscopy

Subject area(s): RNA | Structural Biology & Biophysics