Protein trafficking, signalling and inflammation
Our research investigates intracellular trafficking pathways that control inflammation in macrophages and other cells, including cytokine secretion, phagocytosis, macropinocytosis and Toll-like receptor signalling. Live cell imaging has revealed new surface ruffles and enlarged macropinosomes on activated cells and we have uncovered roles for endocytic receptors, Rab GTPases, PI3Ks and signalling adaptors in TLR signalling.
Keywords
Protein trafficking / cytokine secretion / macrophage activation / GTPases / cell imaging / signalling adaptors / ruffles and macropinosomes / PI3Ks