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RNA regulatory networks

My group investigates the functions of ribonucleoprotein complexes (RNPs) in mammalian cells, focusing on their roles in neuronal differentiation. We developed iCLIP and hiCLIP, methods that identify protein-RNA and RNA-RNA interactions in living cells. Thereby, we gain insights into the diverse transcriptome-wide functions of RNPs, their dynamics and evolution. We also study how aberrant RNPs contribute to age-related neurologic diseases.