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EMBO Member

Jernej Ule

Francis Crick Institute, London | United Kingdom

EMBO 2016 | CouC 18–21

RNA regulatory networks

My group investigates the functions of ribonucleoprotein complexes (RNPs) in mammalian cells, focusing on their roles in neuronal differentiation. We developed iCLIP and hiCLIP, methods that identify protein-RNA and RNA-RNA interactions in living cells. Thereby, we gain insights into the diverse transcriptome-wide functions of RNPs, their dynamics and evolution. We also study how aberrant RNPs contribute to age-related neurologic diseases.

Keywords: RNA regulation / neurobiology / splicing / iCLIP / in-vivo RNA structure

Subject area(s): Genomic & Computational Biology | Neuroscience | RNA