EMBO Associate Member
Joan Massagué
EMBO 1998
Memorial Sloan-Kettering Cancer Center, New York, United States
TGF-beta signaling in stem cells and cancer metastasis
My lab investigates mechanisms that regulate tissue homeostasis and cancer metastasis. We delineated the TGF-beta signaling pathway, a central regulator of cell proliferation and fate in metazoans. We are currently focusing on the regulation of stem cell differentiation. Additionally we are identifying genes and mechanisms that drive dissemination, latency, and organ colonization during metastasis.
Keywords
Signal transduction & cell regulation by the TGF-beta system / role of TGF-beta in cancer / metastasis genes & functions