University, Lausanne | Switzerland
My group is interested in the microenvironment in which a tumor arises and the critical influence that non-cancerous stromal and immune cells can have on tumor progression, metastasis and response to therapy. We investigate both positive and negative signals provided by the normal tissue stroma to the cancer cells, and how the microenvironment can be modified by the cancer cells to produce a variety of factors that enhance tumor malignancy.
Keywords: Tumor microenvironment / mechanisms of metastasis / tumor-promoting macrophages / brain tumors / genetically engineered mouse models of human cancer
Subject area(s): Signal Transduction | Molecular Medicine | Immunology