EMBO Member
Johannes Zuber
EMBO 2022
Former EMBO Young Investigator (2015)
Research Institute of Molecular Pathology (IMP), Vienna, Austria
Finding and understanding cancer dependencies
Our lab develops and applies functional-genetic approaches (advanced CRISPR- and RNAi-based screening methods, chemical-genetic protein degradation, time-resolved transcriptomics) to identify and mechanistically study dependencies in cancer and tumor-associated immune cells. In current projects, we are applying these tools to decipher the regulation and function of transcriptional master regulators and to explore rational combination therapies.
Keywords
Cancer biology / molecular medicine / functional genetics / CRISPR / RNAi / genetic screens / transcriptomics / transcription factors / cancer dependencies / cancer immunity / combination therapies