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EMBO Young Investigator

Johannes Zuber

IMP, Vienna | Austria

YIP 2015

Finding and probing cancer dependencies

Our lab combines genetically engineered cancer models and multiplexed functional-genetic screens to systematically identify cancer-specific dependencies (so-called 'non-oncogene addictions') and study their function and therapeutic potential in a relevant in-vivo setting. One major focus of ongoing projects is the functional exploration of chromatin regulatory pathways that maintain aberrant self-renewal states in leukemia and other cancers.

Keywords: Leukemia / functional cancer genetics / cancer epigenetics / aberrant self-renewal / BRD4

Subject area(s): Chromatin & Transcription | Differentiation & Death | Molecular Medicine