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EMBO Member

John van der Oost

University, Wageningen | Netherlands

EMBO 2013

RNA- and DNA-guided interference in prokaryotes

My group investigates catalytic and signal transduction processes in bacteria and archaea. We aim to use mechanistic insights for a broad spectrum of applications, ranging from biotechnology to gene therapy. Since 2008, we revealed several key features of CRISPR, an RNA-guided adaptive immune system in prokaryotes (Cascade, Cas9, Cpf1). Recently we discovered that a prokaryotic Argonaute is responsible for DNA-guided DNA interference.

Keywords: Bacteria & archaea / mesophiles & thermophiles / prokaryotic anti-virus defense systems / CRISPR / Argonaute

Subject area(s): Microbiology, Virology & Pathogens | RNA