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EMBO Member

Joost Gribnau

Erasmus University MC, Rotterdam | Netherlands

EMBO 2015

Activation of X chromosome inactivation

My laboratory studies the X-chromosome inactivation (XCI) process. This process leads to one transcriptionally inactive X chromosome in every female mammalian cell, required to compensate for dosage differences of X encoded genes between male and female cells. Our research focus is aimed at the identification and characterization of mechanisms directing female specific initiation of XCI, and epigenetic mechanisms involved in the silencing process.

Keywords: X inactivation / transcription factors / stochastics / early mammalian development / Rnf12

Subject area(s): Chromatin & Transcription | Development | Genome Stability & Dynamics