Mouse models of breast cancer
The focus of our laboratory is on the genetic dissection of human breast cancer through the use of genetically engineered mouse models as well as patient-derived breast cancer xenograft models. These models are used to (1) investigate genotype-phenotype relations in mammary tumorigenesis; (2) identify genetic changes involved in breast carcinogenesis; (3) study mechanisms underlying response and (acquired) resistance to anticancer therapy.
Keywords
Breast cancer / mouse models / brca1 / brca2 / therapy resistance