Netherlands Cancer Institute, Amsterdam | Netherlands
The focus of our laboratory is on the genetic dissection of human breast cancer through the use of genetically engineered mouse models as well as patient-derived breast cancer xenograft models. These models are used to (1) investigate genotype-phenotype relations in mammary tumorigenesis; (2) identify genetic changes involved in breast carcinogenesis; (3) study mechanisms underlying response and (acquired) resistance to anticancer therapy.
Keywords: Breast cancer / mouse models / brca1 / brca2 / therapy resistance
Subject area(s): Differentiation & Death | Genome Stability & Dynamics | Genomic & Computational Biology | Molecular Medicine