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EMBO Member

José R. Naranjo

Centro Nacional de Biotecnología (CNB), Madrid | Spain

EMBO 2000

Ca2+-operated transcriptional networks

We investigate the nuclear components of activity- and Ca2+-dependent transcriptional responses in neurons and immune cells to i) understand downstream events that are responsible for plastic changes in synaptic functionality and, ii) to develop tools to intervene in the physiological output processes including learning and memory, pain sensitization and immune response. Our focus is on the Ca2+-dependent transcriptional repressor DREAM.

Keywords: Gene regulation / nuclear calcium / gene structure / neuronal plasticity / neurodegeneration

Subject area(s): Chromatin & Transcription | Molecular Medicine | Neuroscience