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EMBO Member

Joseph Schlessinger

Yale University School of Medicine, New Haven | United States

EMBO 1982

Cell signaling by receptor tyrosine kinases

Our laboratory investigates the mode of action of growth factor receptors and the intracellular signaling pathways that activated in response to growth factor stimulation.Various diseases are caused by dysfunctions in protein tyrosine kinases or in components of signaling pathways that are activated by these enzymes. Our research involves biochemical, genetic approaches as well as x-ray crystallography to elucidate new insights in cell signaling

Keywords: Receptor tyrosine kinases / growth factors / signal transduction pathways / oncogenes / cell growth & differentiation / structure & function of membrane receptors / kinases & phosphatases

Subject area(s): Molecular Medicine | Signal Transduction | Structural Biology & Biophysics