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EMBO Young Investigator

Joseph Yeeles

MRC LMB, Cambridge | United Kingdom

YIP 2020–2024

Mechanisms of chromosome replication

Our lab studies the process of eukaryotic chromosome replication. We focus in particular on the replisome, the complex and highly-regulated molecular machine responsible for accurate and efficient DNA replication. To do so we assemble fully-functional replisomes from individual purified proteins. This enables us to elucidate key replisome mechanisms using functional DNA replication assays and structure determination by electron cryo-microscopy.

Keywords: DNA replication / chromosome replication / replisome / DNA repair / DNA helicase / DNA polymerase

Subject area(s): Genome Stability & Dynamics | Proteins & Biochemistry | Structural Biology & Biophysics