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EMBO Member

Judith Berman

University, Tel Aviv | Israel

EMBO 2019

Genomic & epigenetic stress response mechanisms

We study pathogenic yeasts of humans, and their responses to antifungal drug stress. These include mitotic defects that cause aneuploidy and cell-to-cell heterogeneity driven by non-genetic mechanisms. We investigate the interplay between chromosome instability, membrane and cell wall dynamics, and intracellular localization of antifungal drugs to better understand processes that modulate the amplitude and diversity of phenotypic responses.

Keywords: Pathogenic yeasts / antifungal drug resistance / neocentromeres / aneuploidy / tolerance / in-vivo transposon mutagenesis / population heterogeneity / heteroresistance

Subject area(s): Cellular Metabolism | Genome Stability & Dynamics | Genomic & Computational Biology | Microbiology, Virology & Pathogens