Genomic & epigenetic stress response mechanisms
We study pathogenic yeasts of humans, and their responses to antifungal drug stress. These include mitotic defects that cause aneuploidy and cell-to-cell heterogeneity driven by non-genetic mechanisms. We investigate the interplay between chromosome instability, membrane and cell wall dynamics, and intracellular localization of antifungal drugs to better understand processes that modulate the amplitude and diversity of phenotypic responses.
Keywords
Pathogenic yeasts / antifungal drug resistance / neocentromeres / aneuploidy / tolerance / in-vivo transposon mutagenesis / population heterogeneity / heteroresistance