Karolinska Institutet, Huddinge | Sweden
My lab has a track record in identifying genes for monogenic and complex disorders and studying their functions. We identified the genes for anhidrotic ectodermal dysplasia (EDA) and congenital chloride diarrhea (SLC26A3), the asthma gene NPSR1, the first gene for dyslexia (DYX1C1) and later several more (e.g., ROBO1, CYP19A1). We currently work on early human development focusing on gene expression from zygote to the 8-cell stage.
Keywords: Complex disorders / susceptibility genes / molecular pathogenesis / immune-mediated diseases / neurodevelopmental disorders / human preimplantation development / human embryo genome activation