EMBO Young Investigator
Julian Stingele
YIP 2021–2025
DNA-protein crosslinks and their resolution
My group studies covalent DNA-protein crosslinks (DPCs) and their repair. DPCs are toxic, because they block chromatin processes such as transcription and replication. Proteases of the SPRTN family degrade the protein components of DPCs, which is essential for genome stability and cellular viability. The overarching objective of my work is to reveal the sources of endogenous DPCs and to understand the cellular responses to these threats.
Keywords
Genome stability / DNA repair / DNA-protein crosslinks / SPRTN / endogenous DNA damage