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EMBO Young Investigator

Julian Stingele

Ludwig-Maximilians-Universität, München | Germany

YIP 2021–2025

DNA-protein crosslinks and their resolution

My group studies covalent DNA-protein crosslinks (DPCs) and their repair. DPCs are toxic, because they block chromatin processes such as transcription and replication. Proteases of the SPRTN family degrade the protein components of DPCs, which is essential for genome stability and cellular viability. The overarching objective of my work is to reveal the sources of endogenous DPCs and to understand the cellular responses to these threats.

Keywords: Genome stability / DNA repair / DNA-protein crosslinks / SPRTN / endogenous DNA damage

Subject area(s): Chromatin & Transcription | Genome Stability & Dynamics | Proteins & Biochemistry