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EMBO Young Investigator

Julien Duxin

University of Copenhagen | Denmark

YIP 2021–2025

Basic principles of DNA-protein crosslink repair

Our group studies the essential processes of genome maintenance and duplication, with a particular emphasis in understanding how cytotoxic DNA lesions known as DNA-protein crosslinks are cleared from the genome. To this end, we take advantage of a protein egg extract system derived from African clawed frogs, which offers the opportunity to study genome maintenance processes in great molecular detail.

Keywords: DNA replication / DNA repair / DNA-protein crosslinks / translesion DNA synthesis

Subject area(s): Genome Stability & Dynamics | Proteins & Biochemistry