EMBO Member
Jürgen Knoblich
EMBO 2002 | FelC 05–10 | FelC 11–13 | Council 15–17 | Council 18–20
Former EMBO Young Investigator (2001)
IMBA, Vienna, Austria
Asymmetric cell division in neural stem cells
Our laboratory is interested in the mechanisms that control asymmetric cell division in stem cell lineages. We use the fruit fly Drosophila and mouse genetics to understand how asymmetric divisions control brain development and how defects lead to tumorigenesis. We have also established a 3D culture model that allows us to recapitulate the development of a human brain and to apply our findings to a better understanding of human brain disorders.
Keywords
Asymmetric cell division / stem cell biology / cell polarity / nervous system development / cell fate specification / proliferation control