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EMBO Associate Member

Karen Adelman

Harvard Medical School, Boston | United States

EMBO 2024

Control of coding and non-coding RNA biogenesis

My lab pioneered genomic studies of RNA polymerase II (RNAPII) transcription, revealing that pausing of RNAPII in early elongation is a central regulatory step in metazoan gene expression. Ongoing work probes the interplay between transcription, RNA processing and epigenetic machineries to elucidate the determinants of mature mRNA formation in health and disease.

Keywords: Gene transcription / RNA polymerase II / promoter-proximal pausing / chromatin control / enhancer-promoter communication / nascent RNA-sequencing / transcription elongation

Subject area(s): RNA | Genomic & Computational Biology | Chromatin & Transcription