Control of coding and non-coding RNA biogenesis
My lab pioneered genomic studies of RNA polymerase II (RNAPII) transcription, revealing that pausing of RNAPII in early elongation is a central regulatory step in metazoan gene expression. Ongoing work probes the interplay between transcription, RNA processing and epigenetic machineries to elucidate the determinants of mature mRNA formation in health and disease.
Keywords
Gene transcription / RNA polymerase II / promoter-proximal pausing / chromatin control / enhancer-promoter communication / nascent RNA-sequencing / transcription elongation