EMBO Associate Member
University of California San Diego, La Jolla | United States
EMBO 2026
My lab studies two aspects of cell division, centrosome assembly and cytokinesis, in C. elegans embryos and human cells. We developed centrinone, a PLK4 inhibitor that depletes centrosomes from cells, which revealed therapeutic potential in cancers with high TRIM37 expression and uncovered a p53-based tumor suppressive pathway. We are also using high-content imaging to assign function to ~1000 C. elegans genes essential for embryonic development.
Keywords: centrosome / cytokinesis / cell division / cytoskeleton / embryonic development / C. elegans / functional genomics / cancer
Subject area(s): Cell Cycle | Cell & Tissue Architecture | Development