Ludwig-Maximilians-Universität, München | Germany
My laboratory studies the molecular mechanisms of the cellular responses to genome instabilty and foreign nucleic acids, in particular, how cellular DNA/RNA sensors distinguish right from wrong or self from non-self. We use a combination of structural, molecular and cell biology to address the structures and mechanisms of DNA double-strand break sensors and repair enzymes, chromatin modifying enzymes and antiviral RNA sensors in the innate immune system.
Keywords: DNA repair / chromatin / innate immune system / genome maintenance / structural & molecular biology
Subject area(s): Genome Stability & Dynamics | Proteins & Biochemistry | Structural Biology & Biophysics