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EMBO Member

Kaspar Locher

ETH Zurich | Switzerland

EMBO 2013

Structural biology of membrane proteins

We investigate the molecular mechanisms of various membrane proteins including active transporters (with an emphasis on ABC transporters) and oligosaccharyltransferase. We use X-ray crystallography to determine protein structures at high resolution and in distinct conformations. We reconstitute the purified proteins in proteoliposomes to investigate their in vitro activities and the conformational changes that underpin their functions.

Keywords: ABC transporter / membrane transport protein / X-ray structure determination / oligosaccharyltransferase

Subject area(s): Membranes & Transport | Proteins & Biochemistry | Structural Biology & Biophysics