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EMBO Member

Katalin Karikó

University of Pennsylvania | United States

EMBO 2023

Developing mRNA for therapy

For four decades, my research has been focusing on RNA-mediated mechanisms with the ultimate goal of developing in vitro-transcribed mRNA for protein therapy. I investigated RNA-mediated immune activation and co-discovered that nucleoside modifications suppress immunogenicity of RNA, which widened the therapeutic potentials of mRNA.

Keywords: RNA modification / mRNA vaccine development / COVID-19 / personalized therapeutics / cancer

Subject area(s): Immunology | Microbiology, Virology & Pathogens | Molecular Medicine | RNA