Dynamic behaviour of epithelia in organ formation
My research addresses major questions in organ formation, in particular how molecular events affect physical properties and changes at the tissue scale. We seek to understand the importance of cytoskeletal crosstalk, the coordination of cell behaviours and forces, and the role of spatial and temporal control by upstream transcriptional regulation, studying highly tractable model processes in Drosophila and powerful human organoid culture.
Keywords
Development / tubulogenesis / cytoskeletal crosstalk / cell shape control / epithelial cells / mesenchymal-to-epithelial transition / quantitative imaging / kidney