Mechanisms of ubiquitin-dependent signalling
We are interested in elucidating how protein ubiquitination regulates cell signalling pathways, especially in the context of immune and inflammatory signalling. In particular, we seek to understand the mechanisms underlying substrate selection, chain linkage specificity and overall regulation of the ubiquitination process.
Keywords
Multi-protein complexes / ubiquitin E3 ligases / immunity / inflammation / pathogens / X-ray crystallography / signal transduction