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EMBO Member

Katrin Rittinger

Francis Crick Institute, London | United Kingdom

EMBO 2019

Mechanisms of ubiquitin-dependent signalling

We are interested in elucidating how protein ubiquitination regulates cell signalling pathways, especially in the context of immune and inflammatory signalling. In particular, we seek to understand the mechanisms underlying substrate selection, chain linkage specificity and overall regulation of the ubiquitination process.

Keywords: Multi-protein complexes / ubiquitin E3 ligases / immunity / inflammation / pathogens / X-ray crystallography / signal transduction

Subject area(s): Immunology | Proteins & Biochemistry | Signal Transduction | Structural Biology & Biophysics