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EMBO Associate Member

Kenneth S. Zaret

University of Pennsylvania, Philadelphia | United States

EMBO 2022

Overcoming chromatin to control cell fate

My laboratory investigates how genes are activated and different cell types are specified in embryos, disease, and regeneration. We focus on the dynamics in signaling, transcription factors, and chromatin structure during liver and pancreas development and maturation, and during reprogramming of somatic cells to pluripotency and other cell fates. Our goal is to more efficiently reprogram stem cells and somatic cells for biomedical purposes.

Keywords: Development / genetics / chromatin / transcription / reprogramming

Subject area(s): Chromatin & Transcription | Development | Differentiation & Death