Toxic metabolism and DNA repair in stem cells
My group has for some years worked on DNA crosslink repair. However, our most recent work has shed light into how toxins released from metabolism damage the DNA of stem cells particularly in those that produce blood. Studies carried out by my laboratory have uncovered how the body protects against these toxic metabolites through a dual protection mechanism involving degradation of these metabolites and a specific form of DNA repair.
Keywords
DNA repair / stem cells / haematology / metabolism / human genetics