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EMBO Young Investigator and EMBO Member

Kikuë Tachibana

IMBA, Vienna | Austria

EMBO 2018

Mechanisms of zygotic reprogramming to totipotency

Our research focuses on how chromatin is epigenetically reprogrammed to a totipotent state in mammalian zygotes. We use mechanistic cell biology, spatial genome organization, genomics and genetics to study the conversion of female germ cells by fertilization into embryos, the oocyte-to-zygote transition. Our insights into meiotic chromosome segregation in oocytes are also relevant for egg aneuploidy at advanced maternal age.

Keywords: Totipotency / zygotes / epigenetic reprogramming / chromatin / genome organization / meiosis / oocytes

Subject area(s): Cell Cycle | Chromatin & Transcription | Development | Genome Stability & Dynamics

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