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EMBO Member

Kiyoshi Nagai

1949 – 2019

MRC LMB, Cambridge | United Kingdom

EMBO 1999

Structural & functional studies of the spliceosome

The majority of eukaryotic genes contain non-coding intervening sequences known as introns. Introns are excised from mRNA precursors (pre-mRNA) and exons are spliced together to form continuous protein coding sequences. This reaction is catalysed by the large RNA-protein assembly called the spliceosome. We determine the structure of key RNA-protein and protein-protein complexes that constitute the active centre of the spliceosome.

Keywords: RNA splicing / structural biology / RNA-protein interactions / crystallography

Subject area(s): Proteins & Biochemistry | RNA | Structural Biology & Biophysics