
EMBO Member
Knud H. Nierhaus
DeceasedEMBO 1984
1947 – 2016
Ribosome assembly, structure and functions
My group works on assembly, structure and function of the ribosome. Examples are (i) the assembly of the 50S subunit of bacterial ribosomes, (ii) functional aspects of bacterial initiation (70S scanning initiation) and EF-G dependent translocation, (ii) functions of non-canonical ribosomal factors such as EF3, EF4 (LepA), RsfS (YbeB), Tet(O), and (iv) analysis of ribosomal complexes by means of cryo-EM (together with the Spahn group, Charité, Berlin).
Keywords
Protein biosynthesis / structure & function of ribosomes / ribosome assembly / antibiotics / translation inhibitors