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EMBO Member

Kostas Tokatlidis

University of Glasgow | United Kingdom

EMBO 2013

Mitochondria biogenesis and redox regulation

Our main interest is mitochondria biogenesis and function and its impact on health and disease. The process of mitochondria biogenesis relies on protein import as most mitochondrial proteins are targeted from the cytosol. We focus on proteins of the intermembrane space that undergo oxidative folding. We study the machinery, its molecular mechanism and structural basis and its relevance for redox homeostasis and cell physiology

Keywords: Mitochondria biogenesis / oxidative protein folding / protein targeting / protein assembly / redox signaling

Subject area(s): Cellular Metabolism | Membranes & Transport | Proteins & Biochemistry