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EMBO Member

Lalita Ramakrishnan

MRC LMB, Cambridge | United Kingdom

EMBO 2019

Tuberculosis pathogenesis and immunity

We study mechanisms of pathogenesis, immunity and drug tolerance in tuberculosis taking genetic, molecular, immunological and cell biological approaches. Much of our work focuses on using the zebrafish, particularly in its transparent larval stage, as a genetically tractable model organism. We have made discoveries about tuberculosis pathogenesis that have immediate implications for tuberculosis treatments.

Keywords: Tuberculosis pathogenesis / mycobacterial virulence mechanisms / granuloma / macrophage responses / host-targeting tuberculosis therapies / drug tolerance

Subject area(s): Immunology | Microbiology, Virology & Pathogens | Molecular Medicine