CFTR and TRPM2 ion channel structure and function
We study the structure and function of ion channels focusing on two proteins: the CFTR chloride channel and the TRPM2 cation channel. Our experimental approaches include real-time recording of ionic currents of single ion channel proteins and of large channel populations using the patch-clamp technique, kinetic analysis of current time courses, site-directed mutagenesis, protein biochemistry and structural methods, as well as mathematical modeling.
Keywords
Ion channels / cystic fibrosis / enzyme kinetics / structure-function / gating / CFTR / TRPM2