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EMBO Member

László Csanády

Semmelweis University, Budapest | Hungary

EMBO 2024

CFTR and TRPM2 ion channel structure and function

We study the structure and function of ion channels focusing on two proteins: the CFTR chloride channel and the TRPM2 cation channel. Our experimental approaches include real-time recording of ionic currents of single ion channel proteins and of large channel populations using the patch-clamp technique, kinetic analysis of current time courses, site-directed mutagenesis, protein biochemistry and structural methods, as well as mathematical modeling.

Keywords: Ion channels / cystic fibrosis / enzyme kinetics / structure-function / gating / CFTR / TRPM2

Subject area(s): Proteins & Biochemistry | Molecular Medicine | Membranes & Transport