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EMBO Member

Laura Machesky

Beatson Institute for Cancer Research, Glasgow | United Kingdom

EMBO 2012 | YipC 15–18

Cell migration, invasion and metastasis

We are interested in the impact of actin dynamics on cell migration, cancer cell invasion and metastasis. We also study how actin dynamics regulates membrane trafficking and how this affects cell motility. We are particularly focused on actin assembly via the 7-protein Arp2/3 complex and the WASP family proteins downstream of the Rho-family small GTPases.

Keywords: Cell migration / cytoskeleton / cancer metastasis / cancer invasion / actin dynamics

Subject area(s): Cell & Tissue Architecture | Membranes & Transport | Molecular Medicine